Caveolae Depletion Contributes to Vasorelaxant Effects of Chenodeoxycholic Acid
نویسندگان
چکیده
منابع مشابه
Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis
Accumulation of hydrophobic bile acids in the liver contributes to cholestatic liver injury. Inflammation induced by excessive bile acids is believed to play a crucial role, however, the mechanisms of bile acids triggered inflammatory response remain unclear. Recent studies have highlighted the effect of NLRP3 inflammasome in mediating liver inflammation and fibrosis. In this study, we for the ...
متن کاملComparison of Effects of Chenodeoxycholic Acid and Cholic acid on Diabetic Nephropathy in Kkay Mice
Aims: The main purpose of the present study was to investigate the effects of chenodeoxycholic acid (CDCA) and cholic acid (CA) on diabetic nephropathy in KKAy mice, an animal model of type 2 diabetes. Methods: Ten-week-old male KK-Ay/Ta Jcl (KKAy) mice were randomly divided into 3 groups composed of 8 mice each; CDCA, CA and no drugs. C57BL/6J mice were used as control. Parameters were evaluat...
متن کاملEffects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid.
13C-NMR spectroscopy was used to examine the effect of side chain length on the ionization properties and transmembrane transport rate of 3 alpha,7 alpha-dihydroxy bile acids. When solubilized in taurocholate micelles, [23-13C]nor-chenodeoxycholic acid (nor-CDCA) had a pKa of 6.1, similar to that of CDCA (pKa 6.2), its C24 homologue. In unilamellar phosphatidylcholine vesicles, the pKa of nor-C...
متن کاملEffects of feeding cholic acid and chenodeoxycholic acid on cholesterol absorption and hepatic secretion
Chenodeoxycholic acid (CDCA), in contrast to cholic acid (CA), reduces cholesterol saturation of bile. The mechanisms for these differences were the object of this study. Investigations were carried out in nine white men; three nonobese subjects and one obese subject were fed a weight-maintenance diet, and five obese patients had a reduced caloric intake for weight reduction. They were given a ...
متن کاملM-current preservation contributes to anticonvulsant effects of valproic acid.
Valproic acid (VPA) has been widely used for decades to treat epilepsy; however, its mechanism of action remains poorly understood. Here, we report that the anticonvulsant effects of nonacute VPA treatment involve preservation of the M-current, a low-threshold noninactivating potassium current, during seizures. In a wide variety of neurons, activation of Gq-coupled receptors, such as the m1 mus...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2017
ISSN: 1015-8987,1421-9778
DOI: 10.1159/000478683